Bucks vs. Pacers Prediction: Game 2 Odds & NBA Playoff Expert Picks Tonight

The No. 4 seed Indiana Pacers host the No. 5 seed Milwaukee Bucks tonight (7 p.m. ET, NBA TV) at Gainbridge Fieldhouse in Indianapolis, as we offer our best Bucks vs. Pacers prediction for Game 2 of their NBA playoffs series.
The Pacers are 4.5-point betting favorites for tonight's showdown, with all of the best NBA betting sites offering Indiana with a moneyline of at least -189 in a game featuring a total around 228.
After Game 1 featured the lowest combined scoring total in a Bucks-Pacers matchup all season, our best NBA picks expect more fireworks in Game 2.
📡 How to watch Bucks vs. Pacers live tonight (Game 2)
📅 Tuesday, April 22
🕗 7 p.m. ET
📍 Gainbridge Fieldhouse (Indianapolis)
📺 NBA TV | 🛜 Max
📊 Best Bucks vs. Pacers odds, records, stats & trends tonight
📈 Check out our Bucks vs. Pacers betting info for full team stats and betting line history.
💡 Bucks vs. Pacers predictions, expert picks & best bets: Game 2
✅ Against the spread pick: Pacers -4.5 (-110 via BetMGM) ⭐⭐⭐⭐
✅ Moneyline pick: Pacers (-189 via Caesars) ⭐⭐⭐
✅ Over/Under pick: Over 227.5 (-110 via DraftKings) ⭐⭐⭐⭐

🎯 Bucks vs. Pacers Game 2 prediction
- Pacers 119, Bucks 113
📰 Bucks vs. Pacers Game 2 preview
The ebbs and flows of a typical playoff series would suggest a return to normalcy for the scoring pace after a tighter defensive game in the opener. Prior to Saturday’s game, which totaled only 215 points, the Bucks and Pacers had exceeded this scoring total in all four of their regular-season matchups, with those matchups averaging 238.0 total points per game.
Indiana averages the sixth-most points per home game in the NBA this season (118.3 PPG), and the Pacers also rank 17th in scoring defense. After holding the Bucks below 100 points in Game 1, Indiana figures to see Milwaukee’s best shot as the pace picks up in a more desperate spot for the Bucks in Game 2.
Dating back to the 2019 Eastern Conference Finals, Pacers star Pascal Siakam has logged five straight playoff wins against the Bucks, and kept that streak rolling by matching up effectively against Giannis Antetokounmpo in Game 1.
Over bettors should target this wager at DraftKings for the line at 227.5 rather than the 228.5 mark from BetMGM.
✅ Best bet: Over 227.5 (-110 via DraftKings)
⛹️ Best NBA player prop bet for Bucks vs. Pacers: Game 2
🔎 Our NEW NBA player prop odds tool can help you find the best NBA odds across legal sportsbooks in your area!
🔥 Pascal Siakam Over 20.5 points ⭐⭐⭐⭐
Siakam, who averaged 20.2 points per game on the season, has cleared this scoring line in about half of his contests. He opened the playoffs with a 25-point output against the Bucks in Game 1.
Siakam has had the Bucks’ number in his last five playoff matchups against Milwaukee. He has also posted strong numbers this season when facing the Bucks, reaching 25 or more points in four of the five matchups. Siakam hasn’t scored fewer than 20 points against Milwaukee all year.
The consistency of his scoring against Milwaukee, despite the Bucks’ generally solid defense against opposing power forwards and centers, suggests a particular advantage for Siakam’s ability to regularly defy a strength of Milwaukee’s defense.
💰 Best odds: -105 via BetMGM
🚀 Best same-game parlay (SGP) for Bucks vs. Pacers: Game 2
🧪 Want to make your own SGP? Check out our NEW parlay calculator to get the best odds for any same-game parlay.
📈 Live Bucks vs. Pacers odds & Game 2 betting lines
Latest Bucks vs. Pacers odds from our best sports betting sites.
🪧 Bucks vs. Pacers Game 2 opening odds
Opening odds via BetMGM.
- Spread: Bucks +6.5 (-110) | Pacers -6.5 (-110)
- Moneyline: Bucks +190 | Pacers -235
- Over/Under: Over 225.5 (-110) | Under 225.5 (-110)
💸 Bucks vs. Pacers Game 2 odds movement
While the Pacers opened as 6.5-point favorites to win tonight's matchup with the Bucks, the line has moved to -3.5 in the hours before tipoff.
That comes even with 58% of the spread bets on Indiana, according to the latest betting data from BetMGM, suggesting that sharps could be eyeing the road underdogs tonight after Milwaukee was blown out in Game 1.
The betting total has also ticked up by three points since opening at 225.5. That number had risen to 228.5 ahead of tipoff despite more than half of all O/U bets coming on the Under.
🚑 Bucks vs. Pacers injury report & lineup notes: Game 2
📋 Follow the official NBA injury report for more injury news.
🔮 Expert Bucks vs. Pacers picks
- Bucks vs. Pacers prediction
- Bucks vs. Pacers player props
- Bucks vs. Pacers parlay picks
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