Pistons vs. Knicks Prediction Tonight: NBA Playoffs Game 2 Expert Picks, Odds & Preview

The New York Knicks relied on a 21-0 run late to defeat the Detroit Pistons in Game 1. Our Pistons vs. Knicks prediction and NBA picks dive into why New York will use this dominant stretch as a catalyst as the focus shifts to Game 2 tonight.
The NBA Playoffs are all about adjustments, but will that be enough for Detroit to overcome the Knicks' playoff experience? Our best sports betting apps don't believe so, as they list the hosts as 6-point betting favorites. However, after a closing line of New York -7 in Game 1, the market expects the Pistons to respond at least.
We don't expect the same ahead of Game 2 from Madison Square Garden in New York tonight. Tipoff is set for 7:30 p.m. ET (TNT).
π‘ How to watch Pistons vs. Knicks live (Game 2)
π
Monday, April 21
π 7:30 p.m. ET
π Madison Square Garden (New York)
πΊ TNT | π Max
π Best Pistons vs. Knicks odds, records, stats & trends - Monday, April 21
π Check out our Pistons vs. Knicks matchup info for full team stats and betting line history.
π‘ Pistons vs. Knicks predictions, expert picks & best bets: Game 2
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Against the spread pick: Knicks 1st half spread -3.5 (-105 via Caesars) ββββ
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Moneyline pick: Knicks first half winner/full time winner (-135 via FanDuel) βββββ
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Over/Under pick: Over 221.5 (-110 via FanDuel) ββ

π― Pistons vs. Knicks Game 2 prediction
- Knicks 115, Pistons 108
π° Pistons vs. Knicks Game 2 preview
The Knicks now realize they must take the Pistons seriously, and I believe they will build on their momentum from a 21-0 run in the fourth quarter for a strong start on Monday and establish control of the series.
Fortunately, the Knicks excel at strong starts. They ranked fifth in the league with a net rating of +6.2 in the first half of games during the regular season. That figure was +9.9 in home games, indicating how much the atmosphere of Madison Square Garden enhances these situations.
Had it not been for a 26-foot buzzer-beater from Detroitβs Tobias Harris, New York would have covered the 3.5-point spread in the first half on Saturday. Jalen Brunson gave the Knicks a 57-52 lead with 4.1 seconds remaining before the Pistonsβ 3-pointer just before the break.
There are multiple ways to support a strong start by the Knicks, including their first-half spread. However, I prefer the double result market, paying -135 odds for New York to lead at both the break and the end of the game. DraftKingsβ odds for the same ticket are -160.
β Best bet: Knicks first half winner/full-time winner (-135 via FanDuel)
βΉοΈ Best NBA player prop bet for Pistons vs. Knicks: Game 2
π Our NEW NBA player prop odds tool can help you find the best NBA odds across legal sportsbooks in your area!
π₯ Karl-Anthony Towns Over 14.5 rebounds + assists ββββ
Towns has an unfair playoff reputation, and Iβm hoping people will realize that in this series. In Game 1, he finished with 23 points, 11 rebounds, five assists, two blocks, and four steals. This matchup favors the big man, which is why he has cleared this combo prop in all four contests against Detroit this year. He has averaged 16 rebounds and assists in his four games against the Pistons this season.
Additionally, he boasts an overall 60% hit rate on this line for the 2024-25 season.
FanDuel is the only shop offering this line at 14.5, while the rest of the market has adjusted these odds to 15.5. Take advantage of this discount.
π° Best odds: -138 via FanDuel
π Best same-game parlay (SGP) for Pistons vs. Knicks: Game 2
π§ͺ Want to make your own SGP? Check out our NEW parlay calculator to get the best odds for any same-game parlay.
π Live Pistons vs. Knicks odds & Game 2 betting lines
Latest Pistons vs. Knicks odds from our best sports betting sites.
πͺ§ Pistons vs. Knicks Game 2 opening odds
Opening odds via BetMGM.
- Spread: Pistons +6.5 (-105) | Knicks -6.5 (-115)
- Moneyline: Pistons +225 | Knicks -278
- Over/Under: Over 221.5 (-110) | Under 221.5 (-110)
π Pistons vs. Knicks injury report & lineup notes: Game 2
π Follow the official NBA injury report for more injury news.
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