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Timberwolves vs. Lakers Prediction, Odds & Expert Picks for Tonight: Game 2 NBA Playoff Preview

Shane Jackson

Last Updated: April 22, 2025 6:55 PM EDT • 3 min 6 sec read.

The Los Angeles Lakers struggled mightily in Game 1 against the Minnesota Timberwolves and will be focusing on having a bounce-back performance tonight at Crypto.com Arena for Game 2 (10 p.m. ET, TNT).

Our Timberwolves vs. Lakers prediction and expert picks, part of our Round 1 NBA picks, expect the Lakers to even the series in a tight Game 2. 

📡 How to watch Timberwolves vs. Lakers live Game 2

📅  Tuesday, April 22
🕗  10 p.m. ET
📍  Crypto.com Arena (Los Angeles)
📺  TNT| 🛜  MAX

🔢 Timberwolves vs. Lakers updated betting action 

Betting info via BetMGM. 

  • The Lakers are the 5.5-point betting favorite. That line has not changed since opening
  • The total opened at 216.5 but has since decreased to 210.5
  • 74% of the bets and 69% of the money is on the Over
  • 63% of the bets and 68% of the money is on the Lakers

📊 Best Timberwolves vs. Lakers odds, records, stats & trends

📈 Check out our Timberwolves vs. Lakers matchup info for full team stats and betting line history. 

💡 Timberwolves vs. Lakers predictions, expert picks & best bets: Game 2

✅ Against the spread pick: Timberwolves +5.5 (-106 via FanDuel) ⭐⭐⭐
✅ Moneyline pick: Lakers ML (-225 via BetMGM) ⭐⭐
✅ Over/Under pick: Over 211 (-110 via DraftKings) ⭐⭐⭐⭐

Timberwolves vs. Lakers Game 2 Prediction, Odds & Expert Picks
Pictured: Minnesota Timberwolves center Naz Reid shoots over the defense of Utah Jazz guard Svi Mykhailiuk. Photo by Matt Blewett via Imagn Images.

🎯 Timberwolves vs. Lakers Game 2 prediction

  • Lakers 110, Timberwolves 106

📰 Timberwolves vs. Lakers Game 2 preview

No one other than Luka Doncic (game-high 37 points) showed up for the Lakers in Saturday’s Game 1. They approached that matchup like a regular-season game, failing to match the Timberwolves’ physicality.

I expect the Lakers to respond on Tuesday, particularly on the offensive end. LeBron James (19 points) and Austin Reaves (16) need to be more involved. That trio did a great job of playing off each other during the regular season.

At the same time, I’m not convinced the Lakers have an answer for slowing down the Timberwolves’ offense. Minnesota likely won’t make 21 of their 3-pointers again, but Los Angeles has nobody who can stay in front of Anthony Edwards.

As a result, I prefer to target the discounted total instead. These two teams have finished Under the closing total in all five head-to-head meetings this year, but the mark has dropped from as high as 229.5 (Feb. 27) to its current line of 211.

It’s time to buy low on two talented offensive teams.

✅ Best bet: Over 211 (-110 via DraftKings)

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⛹️ Best NBA player prop bet for Timberwolves vs. Lakers: Game 2

🔎 Our NEW NBA player prop odds tool can help you find the best NBA odds across legal sportsbooks in your area!

🔥 Anthony Edwards Over 4.5 assists ⭐⭐⭐⭐

If you watched “Starting Five” on Netflix in the offseason, you know Edwards was frustrated with how teams defended him last postseason. Opposing teams didn’t make it easy for him, taking the ball out of his hands more often than he would have liked.

If Saturday was any indication, Edwards has learned from last year’s playoff appearance. He finished with 22 points, nine assists, and eight rebounds in the win.

The nine assists stood out to me, especially with the Lakers motivated to send help defenders at him. He made the right reads and must continue to do so for the Wolves to advance past Round 1.

I like his chances of achieving this, especially since FanDuel has Edwards’ assist prop set at 5.5.

💰 Best odds: -140 via DraftKings

🚀 Best same-game parlay (SGP) for Timberwolves vs. Lakers: Game 2

🧪 Want to make your own SGP? Check out our NEW parlay calculator to get the best odds for any same-game parlay.

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📈 Live Timberwolves vs. Lakers odds & Game 2 betting lines

Latest Timberwolves vs. Lakers odds from our best sports betting sites.

🪧 Timberwolves vs. Lakers Game 2 opening odds

Opening odds via BetMGM.

  • Spread: Timberwolves +5.5 (-115) | Lakers -5.5 (-105)
  • Moneyline: Timberwolves +200 | Lakers -250
  • Over/Under: Over 216.5 (-110) | Under 216.5 (-110)

🚑 Timberwolves vs. Lakers injury report & lineup notes: Game 2

📋 Follow the official NBA injury report for more injury news.

🔮 Expert Timberwolves vs. Lakers picks

💵 Best NBA betting sites

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Written By:
Shane Jackson
Shane Jackson has been writing for Sportsbook Review since 2022, though his passion for sports, writing, and betting runs much longer than that. He graduated from the University of Kansas with a journalism degree in 2017 and has been covering sports ever since, working for MLB.com, Manhattan Mercury, Lawrence Journal-World, WynnBET, Bet Chicago Sports, BetNOLA, and BetMGM. Jackson cares about creating quality sports betting content above all else. He uses a mixture of models, information, film, analysis, and a top-down approach to locate every best bet shared for SBR. He never gives out a pick that he wouldn’t be willing to spend his own money on. Jackson is focused on finding +EV bets on a daily basis for a variety of sports such as NCAAF, NCAAB, NFL, NBA, WNBA, and MLB. He usually bets on props but is willing to wager on a spread or total when there is an edge. Don’t ask him how many bets he has placed on a typical college football Saturday. Jackson doesn’t care if you follow him on social media, but his Twitter account has info on how you can follow his bets through multiple third-party platforms. He just wants you to read all the great work from the SBR team.